MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.
Synthesis, Characterization, and Antimicrobial study of new ligands derived from nalidixic acid and their metal complex
INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.
These results indicated that, nalidixicacid reacts as a bidentate ligand bound to the metal ion through theoxygen atoms of carbonyl and carboxylate groups.
The effect of low concentrations of nalidixic acid on ribonucleic acid (RNA) synthesis in Escherichia coli was examined. It was observed that RNA synthesis in exponentially growing cells was not significantly affected, in harmony with previous studies. However, RNA synthesis was markedly depressed by nalidixic acid during starvation for an amino acid or during chloramphenicol treatment. This effect was not caused by increased killing or inhibition of nucleoside triphosphate synthesis by nalidixic acid. The pattern of radioactive uracil incorporation into transfer RNA or ribosomes was not changed by the drug. The sensitivity of RNA synthesis to nalidixic acid in the absence of protein production may be useful in probing the amino acid control of RNA synthesis.
How does Nalidixic Acid inhibit DNA synthesis?
The nano-scale range of thenalidixic acid complexes have been discussed using X-ray powderdiffraction (XRD), scanning electron microscope (SEM) and transmissionelectron microscopy (TEM) analyzer.
Cesium chloride density gradient analysis demonstrated that DNA synthesis after removal of nalidixic acid occurs by a semiconservative mode of replication.
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Induction of Excessive Deoxyribonucleic Acid Synthesis …
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coli TAU-bar, the rate of DNA synthesis, after removal of nalidixic acid, was similar to that of E.
PDF Downloads : Oriental Journal of Chemistry
PHYSIOLOGICAL STATE OF ESCHERICHIA COLI AND THE INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS BY PHENETHYL ALCOHOL.
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How does Nalidixic Acid work/ inhibit bacterial growth /inhibit DNA synthesis?
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