[Reviews] TNT-Audio - Amplifiers tests
Detect many illicitly synthesized forms of stimulants sold online and in head shops nationwide
r/Drugs AMA series: 2C-I - reddit
Non-medical use of fentanyl by individual without can be very dangerous and has resulted in numerous deaths. Even those with opiate tolerances are at high risk for overdoses. Once the fentanyl is in the user's system it is extremely difficult to stop its course because of the nature of absorption. Illicitly synthesized fentanyl powder has also appeared on the United States market. Because of the extremely high strength of pure fentanyl powder, it is very difficult to dilute appropriately, and often the resulting mixture may be far too strong and, consequently, very dangerous.
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The synthesis of fentanyl (-phenyl--(1-phenethyl-4-piperidinyl)propanamide) by Janssen Pharmaceutica was achieved in four steps, starting from 4-piperidinone hydrochloride. The 4-piperidinone hydrochloride was first reacted with 2-phenylethylbromide to give N-phenethyl-4-piperidinone (NPP). Treatment of the NPP intermediate with aniline followed by reduction with sodium borohydride affording 4-anilino--phenethyl-piperidine (ANPP). Finally ANPP and propionic anhydride are reacted to form the amide product.
2C-I can cause tooth grinding, muscle tension, anxiety, nausea ..
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The formation of AgNPs in chitosan was confirmed by both UV-Visible spectrophotometry and transmission electron microscopy (TEM) and the effects of chitosan- concentration and reaction time on the synthesis of AgNPs in chitosan were examined.
N2 - The HIJKLM ring system of ciguatoxin CTX3C was synthesized in a convergent manner. The key steps were a conjugate addition/alkylation sequence, spiroacetalization, intramolecular allylation, ring-closing metathesis, and hydrogenation to form the 36-α-methyl substituent.
2C-I (hydrochloride) (exempt preparation) (CAS 64584 …
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Mephedrone was first synthesized in 1929 but did not become widely known until it was rediscovered in 2003. By 2007 mephedrone was reported to be available for sale on the internet, by 2008 law enforcement agencies had become aware of the compound and by 2010 it had been reported in most of Europe, being particularly prevalent in the United Kingdom. Mephedrone was first made illegal in Israel in 2008, followed by Sweden later that year. In 2010 it was made illegal in many European countries and in December 2010, the EU ruled it illegal across Europe. In Australia, New Zealand, the USA and Canada it is considered illegal as an analog of other illegal drugs and is controlled by laws similar to the Federal Analog Act.
is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and described in his 1991 book PiHKAL: A Chemical Love Story. The drug is used recreationally for its psychedelic and entactogenic effects and is sometimes confused for the analog 25I-NBOMe, nicknamed "Smiles," in the media. 2C-I is commonly sold in its hydrochloride salt form, which is a fluffy, sparkling-white powder, which can sometimes be pressed into a tablet form. 2C-I has been explored as a potential stimulant nootropic in doses between 1 mg and 8 mg.
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25I-NBOMe (Redirected from NBOMe-2CI) 25I-NBOMe ..
25I-NBOMe can be synthesised from 2C-I and 2 ..
25I-NBOMe - Wikipedia
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TNT-Audio: listening and comparison tests of integrated amplifiers, power amplifiers, preamps and phono preamps
Neuroscience and Pharmacology Discussion
Fentanyl was first synthesized by Dr. Paul Janssen in 1960 following the medical inception of pethidine several years earlier. Janssen developed fentanyl by assaying analogues of the structurally-related drug pethidine for activity. The widespread use of fentanyl triggered the production of fentanyl citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry), which entered the clinical practice as a general anaesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogues were developed and introduced into the medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.
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A tetradecapeptide amide, H-Ile-Asn-Leu-Lys-Ala-Ile-Ala-Ala-Leu-Ala-Lys-Lys-Leu-Leu-NH2, corresponding to the entire amino acid sequence of a wasp venom, mastoparan M, was synthesized using the thioanisole-mediated trifluoroacetic acid deprotecting procedure.
25B-NBOMe and its precursor 2C-B: modern trends and …
As of March 2010, there have been no reported studies on the potential neurotoxicity of mephedrone nor is the median lethal dose known. In 2009, one case of sympathomimetic toxicity was reported in the UK after a person took 0.2 g of mephedrone orally and 3.8g subcutaneously. The patient was treated with 1mg of lorazepam and the sympathomimetic features decreased within 6 hours of treatment. The Swedish medical journal reported that mephedrone could theoretically cause the cardiovascular problems associated with the use of cocaine and amphetamines and serotonin syndrome associated with the use of ecstasy and LSD. One case of serotonin syndrome has been reported, where the patient was already prescribed fluoxetine and olanzapine and then took 40 tablets containing mephedrone in one night. He was treated with lorazepam and discharged 15 hours after admission. Both enantiomers of methcathinone, which differs only in the lack of the methyl group on the aryl ring when compared to mephedrone, have been shown to be toxic to rat dopamine neurons, and the S-enantiomer was also toxic against serotonin neurons. Simon Gibbons and Mire Zloh of The School of Pharmacy, University of London stated that based on the chemical similarities between methcathinone and mephedrone, "it is highly likely that mephedrone will display neurotoxicity". However, Brunt and colleagues stated that "extreme caution" should be used when inferring the toxicity of mephedrone from methcathinone, noting that some of the toxicity associated with methcathinone is due to manganese impurities related to its synthesis, rather than the compound itself. They concluded that experimental research is needed to investigate the toxicity of mephedrone. Doctors who treated a 15 year old female suffering from mephedrone intoxication suggested in that like MDMA, mephedrone may promote serotonin-mediated release of antidiuretic hormone resulting in hyponatraemia and an altered mental state. In another case, a 19 year old male was admitted to hospital suffering from inflammation of the heart, 20 hours after taking one gram of mephedrone. The doctors treating the patient stated it was caused by either a direct toxic effect of mephedrone on the heart muscle, or by an immune response. One case of acquired methaemoglobinaemia, where a patient had "bluish lips and fingers", has also been reported, after they snorted one gram of mephedrone. The patient started to recover after being hospitalized and it was not necessary to administer any medication.
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