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1-benzyl-1H-benzimidazole | C14H12N2 - ChemSynthesis

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Synthesis and crystal structure of 1-benzyl-2 ..

The title compound C21H18N2O is a new heterocyclic system deriving from benzimidazole. The of this molecule is built up from two fused six and five-membered rings linked to two benzyl groups. The oxygen and the adjacent carbon atom are located in the 4 e on the twofold axis (0, , 1/4). The fused-ring system is essentially planar, with the maximum deviation of 0.0121 (9) Å for N1 as shown in Fig.1. The benzyl groups are almost perpendicular to the benzimidazole plane but oriented in opposite directions, with a dihedral angle of 81.95 (7). The dihedral angle between the two benzyl rings is abut 60.965 (7)°.

SYNTHESIS GUANIDINE HYDROXY BENZYL BENZIMIDAZOLE 2 …

Benzimidazoles are very useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Benzimidazole and its derivatives are an important class of bioactive molecules in the field of drugs and pharmaceuticals. Benzimidazole derivatives have found applications in diverse therapeutic areas including anti-ulcers, anti-hypertensives, anti-virals, anti-fungals, anti-cancers, (Gravatt 1994; Horton 2003; Kim 1996; Roth 1997).

Synthesis of N-Alkyl-2-thiomethyl Benzimidazoles: A …

As a continuation of our research work devoted to the development of substituted benzimidazol-2-one derivatives (Ouzidan , 2011, 2011), we reported the synthesis of new benzimidazol-2-one derivative by action of benzyl chloride with 1-benzimidazol-2(3)-one in the presence of a catalytic quantity of tetra-n-butylammonium bromide under mild conditions to furnish two compounds: mono-substituted (Ouzidan , 2011) and the title compound (Scheme 1).

For pharmacological and biochemical properties of benzimidazoles, see: Gravatt (1994); Horton (2003); Kim (1996); Roth (1997). Ouzidan (2011,,).

Synthesis of 1-Aminoalkyl-2-benzyl-nitro ..

To a mxture of 1-benzimidazol-2(3)-one (0.2 g, 1.5 mmol), potassium carbonate (0.41 g, 3 mmol) and tetra-n-butylammonium bromide (0.05 g, 0.15 mmol) in DMF (15 ml) was added benzyl chloride (0.34 ml, 3 mmol). Stirring was continued at room temperature for 6 h. The salt was removed by filtration and the filtrate concentrated under reduced pressure. The residue was separated by on a column of silica gel with ethyl acetate/hexane (1/2) as The compound was recrystallized from ethanol to give colourless crystals (yield: 75%).

For pharmacological and biochemical properties of benzimidazoles, see: Gravatt (1994); Horton (2003); Kim (1996); Roth (1997). Ouzidan (2011,,).

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  • Synthesis of Benzoxazoles - Organic Chemistry Portal

    23/09/2006 · Synthesis and Antifungal Activity of Some New Benzimidazole Derivatives

  • 1,2-Amino Alcohols and Their Heterocyclic Derivatives …

    Get supplier listing of 2-(4-Chlorobenzyl)-1H-benzimidazole and equal product

  • ThalesNano Nanotechology Inc - Publications

    Synthesis and analgesic activity of some 1-benzyl-2-substituted-4,5-diphenyl-1H-imidazole derivatives

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PDF Downloads : Oriental Journal of Chemistry

Benzimidazoles are very useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Benzimidazole and its derivatives are an important class of bioactive molecules in the field of drugs and pharmaceuticals. Benzimidazole derivatives have found applications in diverse therapeutic areas including anti-ulcers, anti-hypertensives, anti-virals, anti-fungals, anti-cancers, (Gravatt 1994; Horton 2003; Kim 1996; Roth 1997).

phenethyl benzoate, 94-47-3 - …

As a continuation of our research work devoted to the development of substituted benzimidazol-2-one derivatives (Ouzidan , 2011, 2011), we reported the synthesis of new benzimidazol-2-one derivative by action of benzyl chloride with 1-benzimidazol-2(3)-one in the presence of a catalytic quantity of tetra-n-butylammonium bromide under mild conditions to furnish two compounds: mono-substituted (Ouzidan , 2011) and the title compound (Scheme 1).

Benzimidazole synthesis - Organic Chemistry Portal

The title compound C21H18N2O is a new heterocyclic system deriving from benzimidazole. The of this molecule is built up from two fused six and five-membered rings linked to two benzyl groups. The oxygen and the adjacent carbon atom are located in the 4 e on the twofold axis (0, , 1/4). The fused-ring system is essentially planar, with the maximum deviation of 0.0121 (9) Å for N1 as shown in Fig.1. The benzyl groups are almost perpendicular to the benzimidazole plane but oriented in opposite directions, with a dihedral angle of 81.95 (7). The dihedral angle between the two benzyl rings is abut 60.965 (7)°.

A convenient method for the synthesis of 2-substituted ..

In the mol­ecular structure of the title compound, CHNO, the fused-ring system is essentially planar, the largest deviation from the mean plane being 0.0121 (9) Å. The O atom and adjacent C atom are located in 4 on a twofold axis (0, , 1/4). The two benzyl groups are almost perpendicular to the benzimidazole plane, but point in opposite directions. The dihedral angle between the benzimidazole mean plane and the phenyl ring is 81.95 (5)°, whereas that between the two benzyl groups is 60.96 (7)°.

Bis(2-benzyl-1H-benzimidazole-N(3))dichlorozinc(II) …

For pharmacological and biochemical properties of benzimidazoles, see: Gravatt (1994); Horton (2003); Kim (1996); Roth (1997). Ouzidan (2011,,).

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