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Pinner synthesis | SpringerLink

Pinner Reaction - The Organic Synthesis Database

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Pinner Triazine Synthesis - Chempedia - LookChem

In addition, the diverse biological activities reported for many derivatives of imidates have also drawn the attention of biochemists in the last decade The literature covering the of iminoethers derivatives has been limited However, a review of the chemistry and reactions of iminoethers was published []. The main objective of the present survey is to provide a comprehensive account of the synthetic utility of imidates or imidate N-fonctionnilazed in building various organic heterocyclesand to highlight their potential in evolving better chemotherapeutic agents.

Pinner triazine synthesis - Wikipedia

Imidates can be synthesized by numerous methods Many of these synthesis can also be applied to different substituted imdates derivatives simply by varying the functional groups on the reactants Several approaches are available for synthesis ofimidates as, Pinner, Nef synthesis, hydratation, and alkylation Details of the synthetic procedures are given below.

Pinner synthesis - ResearchGate

On Jan 1, 2002, Jie Jack Li published the chapter: Pinner synthesis in the book: Name Reactions.

AB - A mild, metal-free, and modular route for the preparation of N-styrenyl amidines from N-aryl-α,β-unsaturated nitrones and isocyanates has been developed that accesses an initial oxadiazolidinone intermediate that can undergo CO2 elimination and styrenyl migration. The use of a migration event to install N-styrenyl amidine substituents circumvents a limitation of traditional Pinner-type methods for amidine synthesis that require the use of amine nucleophiles. The modularity of the nitrone and isocyanate reagents provides access to a variety of differentially substituted N-styrenyl amidines. The scope and tolerance of the method are presented, and preliminary mechanistic data for the transformation are discussed.

N2 - A mild, metal-free, and modular route for the preparation of N-styrenyl amidines from N-aryl-α,β-unsaturated nitrones and isocyanates has been developed that accesses an initial oxadiazolidinone intermediate that can undergo CO2 elimination and styrenyl migration. The use of a migration event to install N-styrenyl amidine substituents circumvents a limitation of traditional Pinner-type methods for amidine synthesis that require the use of amine nucleophiles. The modularity of the nitrone and isocyanate reagents provides access to a variety of differentially substituted N-styrenyl amidines. The scope and tolerance of the method are presented, and preliminary mechanistic data for the transformation are discussed.

Open Access Articles- Top Results for Pinner triazine synthesis

known as the Pinner synthesis,~ and subsequent ammonolysis of the resultant imidate ester.

A mild, metal-free, and modular route for the preparation of N-styrenyl amidines from N-aryl-α,β-unsaturated nitrones and isocyanates has been developed that accesses an initial oxadiazolidinone intermediate that can undergo CO2 elimination and styrenyl migration. The use of a migration event to install N-styrenyl amidine substituents circumvents a limitation of traditional Pinner-type methods for amidine synthesis that require the use of amine nucleophiles. The modularity of the nitrone and isocyanate reagents provides access to a variety of differentially substituted N-styrenyl amidines. The scope and tolerance of the method are presented, and preliminary mechanistic data for the transformation are discussed.

Pinner's reaction in 1892 [] is the first synthesis of N-acylated and N-ethoxycarbonylated imidates Indeed, the action of the simple imidates with the acid halides or with the ethyl chloroformate in the presence of a base (triethylamine or pyridine) directlygives the target compounds.

Pinner Reaction (Amidine And Ortho Ester Synthesis) …
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  • Important Organic Synthesis Allfreetiping

    Pinner Triazine Synthesis A

  • Pinner Reaction - Organic Chemistry Portal

    Pinner triazine synthesis

  • The Pinner reaction refers to the acid catalysed ..

    Bromination, Cyanation, Hydrogenation, Pinner synthesis, Grignard reactions, ..

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this is sometimes referred to as a Pinner ..

Pinner and Klein synthesis: In 1877 Pinner and Klein discovered the proton-induced imidate syntheses [,]. They passed anhydrous gaseous hydrogen chloride through a mixture of an alcohol and benzonitrile A crystalline product precipitated, which they identified as an imidate hydrochloride (Scheme 1) Best results in the Pinner reaction are obtained Best results in the Pinnerreaction are obtained with primary or secondary alcohols and aliphatic or aromatic nitriles.

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