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POTASSIUM periodate synthesis a research paper on euthanasia

T1 - Sodium periodate mediated oxidative transformations in organic synthesis

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Periodate Cleavage of 1,2-Diols - ChemTube3D

AB - The synthesis of di-(6-deoxy-β-D-allofuranose) 1,5′:1′,5-dianhydride (8) from 6-deoxy-D-allose is described. Periodate oxidation of 8, followed by borohydride reduction and acetylation, yielded a crystalline 2,4,7,9-tetra(acetoxymethyl)-5.10-dimethyl-1,3,6,8-tetraoxecane (3).

Periodate is a strong oxidant used in organic synthesis and in chemical analysis of manganese

The synthesis and purification of new fluorescently labeled derivatives of GDP and ATP are described. The fluorescent groups are coupled initially through amine-containing linker arms to periodate-oxidized nucleotides. Reduction of the initial product yields primarily a six-membered morpholine-like ring. Fluorescein-labeled GDP, rhodamine-labeled GDP, and fluorescein-labeled ATP were characterized by absorbance spectroscopy and TLC. NMR and FAB-MS studies were carried out on a single nucleotide derivative formed by reacting periodate-oxidized guanosine and benzylamine with subsequent reduction to establish the modification to the ribose moiety. The synthesis of the guanosine-benzylamine conjugate led to a mixture of products that were separated. The predominant product (70%) resulted in conversion of the ribose moiety to a six-membered morpholine-like ring having no hydroxyl group, and the minor product (30%) resulted in an open ring structure having one hydroxyl. When NaCNBH3 was used as the sole reductant, only the product with the morpholine-like ring was formed. These probes were prepared for use in solution studies of the interactions of eukaryotic initiation factor-2 with other components of mammalian protein synthesis initiation.

Sodium Periodate as a Primary Oxidant for Water …

Ho, T.-L., Fieser, M. and Fieser, L. 2011. Sodium Periodate. Fieser and Fieser's Reagents for Organic Synthesis. 530.

The synthesis of di-(6-deoxy-β-D-allofuranose) 1,5′:1′,5-dianhydride (8) from 6-deoxy-D-allose is described. Periodate oxidation of 8, followed by borohydride reduction and acetylation, yielded a crystalline 2,4,7,9-tetra(acetoxymethyl)-5.10-dimethyl-1,3,6,8-tetraoxecane (3).

N2 - The synthesis and purification of new fluorescently labeled derivatives of GDP and ATP are described. The fluorescent groups are coupled initially through amine-containing linker arms to periodate-oxidized nucleotides. Reduction of the initial product yields primarily a six-membered morpholine-like ring. Fluorescein-labeled GDP, rhodamine-labeled GDP, and fluorescein-labeled ATP were characterized by absorbance spectroscopy and TLC. NMR and FAB-MS studies were carried out on a single nucleotide derivative formed by reacting periodate-oxidized guanosine and benzylamine with subsequent reduction to establish the modification to the ribose moiety. The synthesis of the guanosine-benzylamine conjugate led to a mixture of products that were separated. The predominant product (70%) resulted in conversion of the ribose moiety to a six-membered morpholine-like ring having no hydroxyl group, and the minor product (30%) resulted in an open ring structure having one hydroxyl. When NaCNBH3 was used as the sole reductant, only the product with the morpholine-like ring was formed. These probes were prepared for use in solution studies of the interactions of eukaryotic initiation factor-2 with other components of mammalian protein synthesis initiation.

Synthesis of alkyl azides - Organic Chemistry Portal

Periodate oxidation has been extensively used in carbohydrate chemistry for synthesis ..

AB - The synthesis and purification of new fluorescently labeled derivatives of GDP and ATP are described. The fluorescent groups are coupled initially through amine-containing linker arms to periodate-oxidized nucleotides. Reduction of the initial product yields primarily a six-membered morpholine-like ring. Fluorescein-labeled GDP, rhodamine-labeled GDP, and fluorescein-labeled ATP were characterized by absorbance spectroscopy and TLC. NMR and FAB-MS studies were carried out on a single nucleotide derivative formed by reacting periodate-oxidized guanosine and benzylamine with subsequent reduction to establish the modification to the ribose moiety. The synthesis of the guanosine-benzylamine conjugate led to a mixture of products that were separated. The predominant product (70%) resulted in conversion of the ribose moiety to a six-membered morpholine-like ring having no hydroxyl group, and the minor product (30%) resulted in an open ring structure having one hydroxyl. When NaCNBH3 was used as the sole reductant, only the product with the morpholine-like ring was formed. These probes were prepared for use in solution studies of the interactions of eukaryotic initiation factor-2 with other components of mammalian protein synthesis initiation.

For the colorimetric determination of Mn (oxidizes manganese compounds to permanganates), as oxidizing agentPotassium periodate is used as an oxidizing agent in organic synthesis and an analytical reagent for the determination of potassium and cerium. It is also used in colorimetric estimation of manganese. It reacts with ammonium cerium(IV) nitrate to prepare tris[trinitratocerium(IV)] paraperiodate which finds application as an oxidant.

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  • Sigma-Aldrich Online Catalog Product List: Sodium Salts

    Synthesis Classically, periodate was most commonly produced in the form of sodium hydrogen periodate (NaHIO).

  • ProteoChem - Crosslinking Protein Biology and Chemistry

    Syntheses of (Diacetoxyiodo)arenes or Iodylarenes from Iodoarenes, with Sodium Periodate as the Oxidant

  • Acta Chemica Scandinavica 1947 - 1999

    Periodate - Wikipedia

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Sigma-Aldrich Online Catalog Product List: Ammonium Salts

N2 - The synthesis of di-(6-deoxy-β-D-allofuranose) 1,5′:1′,5-dianhydride (8) from 6-deoxy-D-allose is described. Periodate oxidation of 8, followed by borohydride reduction and acetylation, yielded a crystalline 2,4,7,9-tetra(acetoxymethyl)-5.10-dimethyl-1,3,6,8-tetraoxecane (3).

Fluoride Chemical - 4-Aminobutyric Acid Manufacturer …

N2 - Crystalline Bacillus subtilis alpha-amylase hydrolyses arnylopectin to a mixture Of D-gIUCOSe, maltose, and branched oligosaccharides (alpha-limit dextrins). The smallest such dextrin formed under the conditions of the experiment is a pentasaccharide. A combination of methylation analysis, periodate oxidation, and frag- mentation analysis with acid narrowed the pentasaccharide structure to two possibilities, but failed to distinguish between them. A rigid proof that the dextrin has the structure 6'-a-maltosylmaltotriose was obtained by application of enzymic degradation. Finally, the structure of the pentasaccharide was confirmed by enzymic synthesis. It is shown that the structural analysis of such oligosaccharides, derived from amylopectin, can be made by the use of enzymes alone, without resort to the more time-consuming, less-specific, and less-sensitive methods of chemical analysis. Conclusions are drawn regarding the action pattern of the B. subtilis arnylase.

Cellulose Chemistry and Technology

Crystalline Bacillus subtilis alpha-amylase hydrolyses arnylopectin to a mixture Of D-gIUCOSe, maltose, and branched oligosaccharides (alpha-limit dextrins). The smallest such dextrin formed under the conditions of the experiment is a pentasaccharide. A combination of methylation analysis, periodate oxidation, and frag- mentation analysis with acid narrowed the pentasaccharide structure to two possibilities, but failed to distinguish between them. A rigid proof that the dextrin has the structure 6'-a-maltosylmaltotriose was obtained by application of enzymic degradation. Finally, the structure of the pentasaccharide was confirmed by enzymic synthesis. It is shown that the structural analysis of such oligosaccharides, derived from amylopectin, can be made by the use of enzymes alone, without resort to the more time-consuming, less-specific, and less-sensitive methods of chemical analysis. Conclusions are drawn regarding the action pattern of the B. subtilis arnylase.

Cellulose Chemistry and Tehnology ..

More particularly, the invention relates to improved methods for synthesizing oligonucleotides wherein periodate salts are used (e.g., in organic solvents) as an oxidation reagent in oligonucleotide synthesis (e.g., for automated phosphoramidite synthesis of oligonucleotides).

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