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Causal Agent-Cancer Links in Haz-Map

Varmuza S and Mann M (1994) Genomic imprinting – defusing the ovarian time bomb. Trends in Genetics 10(4): 118–123.

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Immediately after physical recovery Dr. Harlow described Gage as follows: “Remembers passing and past events correctly, as well before as since the injury. Intellectual manifestations feeble, being exceedingly capricious and childish, but with a will as indomitable as ever; is particularly obstinate; will not yield to restraint when it conflicts with his desires.” Dr Harlow reports that Gage’s employers, “who regarded him as the most efficient and capable foreman ... considered the change in his mind so marked that they could not give him his place again.... He is fitful, irreverent, indulging at times in the grossest profanity (which was not previously his custom), manifesting but little deference for his fellows, impatient of restraint or advice when it conflicts with his desires.... A child in his intellectual capacity and manifestations, he has the animal passions of a strong man.... His mind was radically changed, so decidedly that his friends and acquaintances said he was ‘no longer Gage (, ).

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Refusing the ovarian time bomb

Any attempt to generalize from these studies must, however, consider that these survivors may not be typical of the spectrum of the childhood malignancies. For instance, familial retinoblastoma and Wilms tumor are much more often bilateral (i.e., multifocal) than are sporadic cases and confer a greater risk of death (or failure to marry and reproduce) than do their non-familial counterparts. Nevertheless, although many of the children in the Mulvihill series were still quite young at the time of the reports, so that the ultimate estimate of cancer incidence below the age of 20 years will undoubtedly be greater, these empirical data suggest that a transmissible germinal mutation is involved in a fraction of the childhood tumors that is much smaller than the figures mentioned above for retinoblastoma and Wilms tumor. The sib recurrence risks lead to a similar conclusion (see Leck 1977).

After the raid was finished, GAG headquarters was visited by Luke and Mara Jade Skywalker, who had heard news of the events and were worried about Ben's condition. Mara Skywalker was shocked by Ben's military-like mannerisms, as being around the adult males of the GAG had caused him to imitate them without knowing. Skywalker had indeed formed a bond with the GAG members during his time with them. However, Solo's increasingly dark actions had drawn the attention of Luke Skywalker and several other Jedi, who were concerned for Ben due to the great influence that Solo had on him. Even Jaina Solo, Jacen Solo's own sister, recommended to Luke Skywalker that he find another teacher for Ben. In the meantime, Skywalker continued serving in the GAG. He was stationed with Jacen Solo and the 967 Commando at a vehicle checkpoint in the lower levels of Galactic City, this time in a neighborhood that was not Corellian. This was justified by one of the highest ranking GAG members, , by saying that not all threats to domestic security were Corellian. Shevu then announced their reason for being there; their Customs and Immigrations department received a tip-off about three Corellian agents and a bounty hunter they had made contact with, and the CSF had tracked their location.

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Evolutionary Genetic Models of the Ovarian Time Bomb Hypothesis for the Evolution of Genomic Imprinting Genetics

They were met upon landing by an Aing-Tii named , who acted as their liaison with the Aing-Tii Monks. Tadar'Ro took them to a house created for , a former smuggler who had once stayed with the Aing-Tii, where they were to live while learning with the Aing-Tii. Tadar'Ro had previously instructed Jacen Solo during his five-year sojourn, and the Skywalkers believed that Tadar'Ro could tell them of the time Solo had spent with the Aing-Tii, as well as teach Skywalker the technique of flow-walking. Tadar'Ro agreed, in exchange for one service; that the Skywalkers examine the , sacred artifacts taken from all over the galaxy by the Aing-Tii. The Aing-Tii were forbidden to touch the Relics, but outsiders were not. Tensions had recently risen among the Aing-Tii, and Tadar'Ro hoped that the Skywalkers would find a revelation from the Relics that would settle them. The Skywalkers agreed to this deal, although Luke was displeased by Skywalker's eagerness to learn the power of flow-walking. After they returned to the house, they discovered Car'das' journals detailing his experiences amongst the Aing-Tii.

The Skywalkers were sent on many journeys to retrieve more of these Relics and gained the trust—and eventually the friendship—of Tadar'Ro. Meanwhile, they continued to train in the Aing-Tii's exotic Force powers, and one day Skywalker was deemed ready to learn flow-walking. Although Luke was wary of flow-walking, believing it would cause his son pain, Skywalker continued with the training. One night as the Skywalkers slept aboard the , they came under attack by a mysterious assailant wielding a , who had somehow found his way onto the ship. The intruder disappeared as quickly as he arrived, though Luke believed that the attacker was another Aing-Tii. The Skywalkers went to Tadar'Ro for answers, and he agreed that the assailant was an Aing-Tii. Tadar'Ro stated that it was time to journey to the , a series of caverns where the Relics were placed by the Aing-Tii, so they could examine the Relics.

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Skywalker and Shevu waited until Caedus left on the to go to and went to the Galactic Alliance fleet hangar where the StealthX was. Upon examining the starfighter, the they were using found several strands of hair with traces of blood in the fighter, which would implicate Caedus as the killer if the hair was Mara Jade's. Although they were chanced upon by Heol Girdun, one of Caedus' top men, while examining the StealthX, Girdun did not suspect that they were up to anything suspicious. Skywalker and Shevu returned to Endor on the freighter with the evidence in tow, where they met with Luke. By the time he returned, his father was preparing to leave to fight at Fondor, a mission that Skywalker was not allowed on. Skywalker compared the hairs he had taken from Caedus' StealthX with hair on one of Mara Jade's old brushes, which brought up a positive match on a forensic droid. In one fell swoop, Skywalker had confirmed that Caedus was indeed Mara Jade's killer. Excited and triumphant, Skywalker raced back to his father and gave him the news.

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Sergei Sergeievich Korsakoff; Sergei Sergeyevich Korsakov (RU) emphasized the association of with a specific pattern of mental disturbance— — as follows: "This mental disorder appears at times in the form of sharply delineated irritable weakness of the mental sphere, at times in the form of confusion with characteristic mistakes in orientation for place, time and situation, and at times as an almost pure form of acute amnesia, where the recent memory is most severely involved, while the remote memory is well preserved . . . Some have suffered so widespread memory loss that they literally forget everything immediately.” This syndrome is characterized by a severe memory defect, especially for recent events, for which the patient compensates by confabulation (). Korsakoff wrote on paranoia ( as he described it in his textbook) and classified psychiatric illnesses (). Known as a humanitarian, he improved conditions in mental institutions. He was the first great psychiatrist in Russia. He is considered a as were Philippe Pinel (FR) and Jean-Martin Charcot (FR).

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After his sentencing, Luke Skywalker appointed Jedi Master interim Grand Master in a session of the Jedi High Council. Ben Skywalker approached him after the meeting and insisted that he accompany his father during his time away from the Order. Luke reluctantly allowed him to, and Skywalker packed up his belongings and said his farewells to his friends and family. The two took a shuttle to the local spaceport, where they left Coruscant in the . The Skywalkers, who had made the decision to retrace Jacen Solo's five-year journey through the galaxy following the Yuuzhan Vong War, first went to the planet of . Dorin was the home of the , a Force-based organization consisting of the native species, which had been visited by Solo on his voyage. They landed in the city of , and after an inspection of their ship they went to the . Wearing in the helium-rich atmosphere, they were met at the entrance by a Baran Do named , who refused them entry until they proved their identity by besting her in hand-to-hand combat. Ben was sent out to fight Paan and defeated the Baran Do Sage.

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