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A method for the large-scale synthesis of psilocybin was reported by a Japanese group in 2003

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Concise Large-Scale Synthesis of Psilocin and Psilocybin, ..

The American ethnologist and his wife discovered that the ancient religious practices of the Indians in a remote village of Mexico included ingestion of mushrooms. In 1957, they published a magazine article (Seeking the Magic Mushroom), where they described the occurrence of hallucinatory experiences during these rituals. They were accompanied on a later expedition by the French mycologist , director of the , when it was possible to identify several of the fungi as Psilocybe species. Heim was able to successfully cultivate the mushroom in France, and sent samples to the Swiss chemist for analysis. Hofmann, who had previously discovered and experimented with , was the first to recognize the importance and chemical structure of the pure compounds he called psilocybin and psilocin. Leading a research group that was able to isolate and identify the compounds from , Hofmann was aided in the discovery process by his willingness to ingest mushroom . He and his colleagues later synthesized a number of compounds chemically related to the naturally occurring psilocybin:

Concise Large-Scale Synthesis of Psilocin and Psilocybin (Shirota, Hakamata & Goda) ..

Psilocybin (O-phosphoryl-4-hydroxy-N,N-) is a that is converted into the active compound in the body by a reaction. This takes place under strongly conditions, or under physiological conditions in the body, through the action of called . Psilocybin is a compound having a derived from and containing a ring configuration called an linked to an . It bears a close structural resemblance to the (5-hydroxytryptamine). Psilocybin is a that is in water, moderately soluble in and , and insoluble in most . Exposure to light is detrimental to the stability of of psilocybin, and will cause it to rapidly —an important consideration when using it as an analytical . A method for the large-scale synthesis of psilocybin was reported by a Japanese group in 2003.

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A method for the large-scale synthesis of psilocybin was reported by a ..

In the early 1960s, became the testing ground of psilocybin, through the efforts of and his associate Richard Alpert (now known as ). Leary was able to obtain synthesized psilocybin from Hofmann through Hofmann's employer, Sandoz pharmaceutical (now ). Although a number of experiments in the early 1960s demonstrated positive results using psilocybin in clinical psychiatry, the hysteria of the times swept psilocybin along with it into the of illicit drugs in 1970. The 1970s would witness the emergence of psilocybin as the "entheogen of choice". This was due in large part to a wide dissemination of information on the topic, which even included fictional works such as those by , and several books that taught the technique of growing one's own psilocybin mushrooms. One of the most popular of these books was produced under the pseudonyms O.T. Oss and O.N. Oeric by J. Bigwood, D.J. McKenna, K. Harrison McKenna and T.K. McKenna, entitled Psilocybin: Magic Mushroom Grower's Guide. Over 100,000 copies had been sold by 1981:

Psilocybin, псилоцибин , بسيلوسيبين , 赛洛西宾 , « New …

Osamu Shirota and colleagues reported a method for the large-scale synthesis of psilocybin ..

Osamu Shirota and colleagues reported a method for the large-scale synthesis of psilocybin without ..
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