Biotechnology - Deniz Ekinci (AvE4EvA, 2015) ..
and Evaluation of the Antioxidant Capacity of Polyrutin and ..
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Statins are the most commonly prescribed drugs for the treatment of dyslipidemia. They are also recommended in primary and secondary prevention of cardiovascular disease. In addition to decreasing cholesterol synthesis, statins interfere with the synthesis of isoprenoid intermediates, which may explain many of their pleiotropic properties, including their antioxidant effects.
There is widespread recognition of the role of oxidative stress in the pathogenesis of many diseases, including HF. ROS interfere with various processes that affect cardiac structure and function, contributing to apoptosis and mitochondrial dysfunction in cardiomyocytes, contractile dysfunction, myocardial fibrosis and hypertrophy, endothelial dysfunction and atherosclerosis. Statins reduce ROS levels and increase NO synthesis, thereby improving cardiac redox balance. These effects are mainly mediated by inhibition of pro-oxidant enzymes such as Nox and by stimulation of the expression, activity and stability of eNOS. In addition, statins stimulate other antioxidant enzymes and help control inflammatory processes. Statins thus have effects on various molecules that are central to both oxidative stress and inflammation, notably by stimulating the synthesis of 15-epi-LXA, which has pro-resolving, anti-inflammatory and antioxidant properties. Their antioxidant effects have been demonstrated in several cardiovascular conditions, including HF, CAD and AF, mainly in the early stages of these diseases ().
Chemical structure and bioactive properties of rutin and polyrutin
It has recently been shown that statins reduce inflammation by stimulating the synthesis of 15-epi-lipoxin A (15-epi-LXA), which has pro-resolving, anti-inflammatory, antioxidant, vasodilatory and antiproliferative properties (). Synthesis of 15-epi-LXA from arachidonic acid involves the sequential action of cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX). Statins induce expression and S-nitrosylation of COX-2, resulting in the synthesis of 15R-hydroxyeicosatetraenoic acid, which is then converted via 5-LOX to 15-epi-LXA (). Treatment with atorvastatin significantly increased the synthesis of 15-epi-LXA in rat myocardium via S-nitrosylation of COX-2. In an animal model of airway inflammation, treatment with lovastatin also induced the formation of 15-epi-LXA and markedly reduced acute lung inflammation. Furthermore, in-vitro lovastatin increased 15-epi-LXA production during interactions between polymorphonuclear cells and human airway epithelial cells primed with cytokines ().
19/12/2017 · Request (PDF) | Enzymatic Synthesis..
CyTA - Journal of Food - Taylor & Francis
Investigation of a Green Process for the Polymerization …
their antioxidant properties are ..
A fraction of a reaction product wherein said reaction product is produced by an enzymatic polymerization of a ..
Enzymatic synthesis and various properties ..
| Rutin, quercetin-3-rutinoside, is one of the most famous glycosides of flavonoid and widely present in many plants.
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