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Designing polyester vascular prostheses for the future

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Bio Mechanics of Human Common Carotid Artery and Design

Vascular implants belong to a specialised class of medical textiles. The basic purpose of a vascular implant (graft and stent) is to act as an artificial conduit or substitute for a diseased artery. However, the long-term healing function depends on its ability to mimic the mechanical and biological behaviour of the artery. This requires a thorough understanding of the structure and function of an artery, which can then be translated into a synthetic structure based on the capabilities of the manufacturing method utilised. Common textile manufacturing techniques, such as weaving, knitting, braiding, and electrospinning, are frequently used to design vascular implants for research and commercial purposes for the past decades. However, the ability to match attributes of a vascular substitute to those of a native artery still remains a challenge. The synthetic implants have been found to cause disturbance in biological, biomechanical, and hemodynamic parameters at the implant site, which has been widely attributed to their structural design. In this work, we reviewed the design aspect of textile vascular implants and compared them to the structure of a natural artery as a basis for assessing the level of success as an implant. The outcome of this work is expected to encourage future design strategies for developing improved long lasting vascular implants.

Biomechanics of human common carotid artery and design of novel ..

The woven graft development timeline suggests that this technology has shown biomechanical benefits of using new structural components but there are very limited attempts which focus on improvising conventional weave designs to suit the arterial site. Knitted structures appear to be a suitable candidate for vascular implant application owing to their inherent structural and design flexibility. Also, anisotropic elasticity property (axial > circumferential) in knitted structures is similar to that of the native artery, which is an advantage over woven structures. Currently, some of the latest developments in woven and knitted grafts use biological coatings to improved tissue growth and design modifications to match the implant site anatomy, while the lack of innovation from material and biomechanical aspect is evident in new commercial products (). The future products may require a combined input from advanced textile designing and biomechanics together in order to realise the full clinical potential of textile grafts. The helical arrangement of constituent filaments/wires give braided structures a design advantage over woven and knitted structures to mimic the helical geometry of collagen and elastin fibres in an artery. However, the focus on this aspect of braided stent improvement is mostly unrealised. Since, braided stents are deployed in their fully expanded state (helix angle approaching 90°), the low stress radial expansion property owing to helical geometry is completely lost (). The use of elastic filaments and design of bio-component structures can be a future prospect for developing compliant braided stent devices. Expanded polytetrafluoroethylene (ePTFE) is an inert fluorocarbon polymer (stiffness: 0.5 GPa, tensile strength: 14–18 MPa), which is developed by heating, stretching, and extruding process resulting in a porous polymeric structure. Non-textile grafts made from ePTFE are currently used in the clinics as medium diameter grafts (7–9 mm) for peripheral vascular diseases. However, ePTFE grafts are not viable as conduits for small diameter (). There have been numerous investigations into endothelial cell seeding and surface functionalization of ePFTE grafts to improve their clinical performance as small diameter grafts. Current efforts have yet to produce a small diameter synthetic graft that is comparable to an autologous graft. Electrospinning technique has proven to be a promising option for small diameter grafts in many in vitro and animal studies. In comparison to established textile manufacturing methods (weaving, knitting, braiding), this technology is equipped with much higher levels of design flexibility in terms of material variety (natural, synthetic), structural heterogeneity (multi-layer, multi-component), and therapeutic ability (drug delivery). However, development of an off-the-shelf electrospun graft product capable of achieving rapid cell coverage with minimised risk of thrombosis, intimal hyperplasia, and mechanical failure has yet to be achieved.

Long-Term Biostability of Pet Vascular Prostheses

Postoperative dilation of knitted Dacron aortic bifurcation ..

Synthetic vascular implants are currently manufactured using standard textile manufacturing techniques such as weaving, knitting, braiding and electrospinning. A number of reviews have reported on the mechanical property comparisons of different types of vascular grafts and their clinical performance [,,]. In 1986, Pourdeyhimi and Wagner presented an extensive review focusing on structures of the synthetic grafts to explain the reported clinical observations of these grafts [,]. However, recent studies on grafts and stents rarely consider the effect manufacturing techniques have on the structure. This paper will discuss the structure of vascular implants produced by different textile manufacturing methods and analyse them with respect to the arterial wall structure. The analysis is done while following the development timeline of these manufacturing techniques in the vascular implant industry. This approach will provide an understanding of the degree of success, which has been achieved by textile-based implants in mimicking the mechanics of native arteries since their first clinical introduction. Some innovative design concepts, which have attempted to reduce the mechanical property mismatch between the implant and the host artery, are also discussed. These works are thought to encourage the design of longer lasting vascular implants in future.

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