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Ascorbate induction of collagen synthesis as a means …

T1 - Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction

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Glucocorticoids and Collagen Synthesis: Comparison of …

The main results of this study show that high glucose concentration in the culture media increases gene expression and protein synthesis of collagen types I and III, particularly, in cells of the posterior longitudinal ligament of rat cervical spine; this action mimics the effects of rh TGF-β1 on ligament cell collagen synthesis. In fact, the stimulation of collagen synthesis by high glucose appears to be mediated largely, or at least in part, by bioactivities of endogenous TGF-β1.

Glucocorticoids and Collagen Synthesis: ..

However, the compounds with a stimulatory effect on collagen synthesis did not influence the activities of collagenase type I, gelatinases A and B, and stromelysin.

Collagen Synthesis | Collagen | Lysine - Scribd

On the contrary, all compounds stimulated the activity of prolidase which catalyzes the final step of collagen degradation and plays an important role in collagen biosynthesis.

Stimulation of collagen biosynthesis was not due to an increase in cell proliferation, because no differences in DNA content between the compound-treated and untreated cells were observed.

30/12/2017 · Synthesis of collagen: ..

In contrast, the compounds apigenin 7-O-methylglucuronide and pectolinarin which normalized collagen synthesis in OI cells may exert their effects through β1-integrin-mediated signaling.

Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action.

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  • Structure and synthesis of collagen in the ..

    KW - Collagen synthesis

  • Collagen and Elastin Synthesis in Human Stroma and …

    Tranilast (3-100 μM) did not inhibit prolyl hydroxylase (the rate-limiting enzyme in collagen synthesis) activity.

  • the synthesis of collagen and ..

    Decreased collagen synthesis …

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only accounts for acute induction of collagen synthesis by ..

Of the compounds tested, apigenin glycosides 7-O-glucuronide, 7-O-methylglucuronide and pectolinarin at 30 µM were found to significantly induce collagen type I synthesis in OI fibroblasts without an effect on the overall protein synthesis.

Collagen synthesis by mesenchymal stem cells and …

Introduction: Skin aging may occur as a result of increased free radicals in the body. Vitamin E, the major chain-breaking antioxidant, prevents propagation of oxidative stress, especially in biological membranes. In this study, the molecular mechanism of tocotrienol-rich fraction (TRF) in preventing oxidative stressinduced skin aging was evaluated by determining the rate of total collagen synthesis and its gene expression in human skin fibroblasts. Material and methods: Primary culture of human skin fibroblasts was derived from circumcision foreskin of 9 to 12 year-old boys. Fibroblast cells were divided into 5 different treatment groups: untreated control, hydrogen peroxide (H 2O2)- induced oxidative stress (20 μM H 2O2 exposure for 2 weeks), TRF treatment, and pre- and post-treatment of TRF to H2O2-induced oxidative stress. Results: Our results showed that H2O2-induced oxidative stress decreased the rate of total collagen synthesis and down-regulated COL I and COL III in skin fibroblasts. Pre-treatment of TRF protected against H 2O2-induced oxidative stress as shown by increase in total collagen synthesis and up-regulation of COL I and COL III (p 2O2-induced oxidative stress were not observed in the post-treated fibroblasts. Conclusions: Tocotrienol-rich fraction protects against H2O2-induced oxidative stress in human skin fibroblast culture by modulating the expression of COL I and COL III genes with concomitant increase in the rate of total collagen synthesis. These findings may indicate TRF protection against oxidative stressinduced skin aging.

and collagen I synthesis of rat CFs and the mechanism

AB - This report provides evidence from a number of different approaches (i.e., comparison of cell shape in 1-μm sections of photodamaged versus healthy skin at the light microscopic level; comparison of cell shape and apposition to collagen fibrils in ultrathin sections of the same tissues examined by transmission electron microscopy, and fluorescence staining for adhesion site protein expression and actin filament architecture in frozen tissue sections) that dermal cells in healthy skin are attached to collagen fibrils over a large part of the cell border, have a flattened/spread (two-dimensional) appearance and have abundant actin in their cytoplasm. In contrast, cells in photodamaged skin are often in contact with fragmented collagen or amorphous debris rather than intact collagen, have a collapsed/elongated shape, and have a lower amount of actin. Collagen synthesis is reduced in severely photodamaged skin relative to collagen synthesis in corresponding sun-protected skin (N Engl J Wed 329:530, 1993). We hypothesize that fibroblasts in severely damaged skin have less interaction with intact collagen and as a result experience a reduction in mechanical tension. Decreased collagen synthesis is (presumed to be) the result.

13/07/2015 · Regulation of Collagen Synthesis

N2 - Introduction: Skin aging may occur as a result of increased free radicals in the body. Vitamin E, the major chain-breaking antioxidant, prevents propagation of oxidative stress, especially in biological membranes. In this study, the molecular mechanism of tocotrienol-rich fraction (TRF) in preventing oxidative stressinduced skin aging was evaluated by determining the rate of total collagen synthesis and its gene expression in human skin fibroblasts. Material and methods: Primary culture of human skin fibroblasts was derived from circumcision foreskin of 9 to 12 year-old boys. Fibroblast cells were divided into 5 different treatment groups: untreated control, hydrogen peroxide (H 2O2)- induced oxidative stress (20 μM H 2O2 exposure for 2 weeks), TRF treatment, and pre- and post-treatment of TRF to H2O2-induced oxidative stress. Results: Our results showed that H2O2-induced oxidative stress decreased the rate of total collagen synthesis and down-regulated COL I and COL III in skin fibroblasts. Pre-treatment of TRF protected against H 2O2-induced oxidative stress as shown by increase in total collagen synthesis and up-regulation of COL I and COL III (p

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