The Synthesis of Cholesterol. - Cholesterol-And …
The end products of cholesterol utilization are the bile acids
High Cholesterol, APOE Gene and Diet - GB HealthWatch
Cholesterol is an essential component of cell membranes and the precursor for the synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially in a membranous world (especially the last steps), where the enzymes, substrates, and products involved tend to be extremely hydrophobic. The importance of cholesterol has increased in the past half-century because of its association with cardiovascular diseases, which are considered one of the leading causes of death worldwide. In light of the current need for new drugs capable of controlling the levels of cholesterol in the bloodstream, it is important to understand how cholesterol is synthesized in the organism and identify the main enzymes involved in this process. Taking this into account, this review presents a detailed description of several enzymes involved in the biosynthesis of cholesterol. In this regard, the structure and catalytic mechanism of the enzymes involved in cholesterol biosynthesis, from the initial two-carbon acetyl-CoA building block, will be reviewed and their current pharmacological importance discussed. We believe that this review may contribute to a deeper level of understanding of cholesterol metabolism and that it will serve as a useful resource for future studies of the cholesterol biosynthesis pathway.
Krakowiak PA, Wassif CA, Kratz L, et al. (2003) Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5‐desaturase deficiency. Human Molecular Genetics 12 (13): 1631–1641.
Cholesterol Chemistry 101 — The Hydroxyl Group
Xu G, Salen G, Shefer S, et al. (1995) Treatment of the cholesterol biosynthetic defect in Smith–Lemli–Opitz syndrome reproduced in rats by BM 15.766. Gastroenterology 109 (4): 1301–1307.
Xu G, Servatius RJ, Shefer S, et al. (1998) Relationship between abnormal cholesterol synthesis and retarded learning in rats. Metabolism, Clinical and Experimental 47 (7): 878–882.
Cholesterol Synthesis Pathway - YouTube
Cholesterol is an important biochemical, medical, and commercial molecule. In the pathway for cholesterol biosynthesis, biochemistry textbooks discuss the synthesis of lanosterol from acetate in detail. However, the conversion of lanosterol to cholesterol is most often simply indicated as a multistep process, without elaboration. A pathway for the conversion of lanosterol to cholesterol, based on recent results from the primary research literature, is presented in this paper. Each reaction is discussed, the pathway is discussed within the context of general biochemical transformations, a summary of cholesterol homeostasis is presented, and enzyme deficiencies that give rise to diseases are given.
Wassif CA, Krakowiak PA, Wright BS, et al. (2005) Residual cholesterol synthesis and simvastatin induction of cholesterol synthesis in Smith–Lemli–Opitz syndrome fibroblasts. Molecular Genetics and Metabolism 85 (2): 96–107. Epub February 5.
Cholesterol Biosynthesis (Homo sapiens) - WikiPathways
Cholesterol biosynthesis and metabolism.
Cholesterol - Diagnosis:Diet
15/01/2017 · Cholesterol biosynthesis and ..
Cholesterol levels in the body come from two sources, dietary intake and biosynthesis
Lipids Metabolism | Cholesterol | Biosynthesis
Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals
Cholesterol Biosynthesis - UMaine Chemistry Department
Sikora DM, Ruggiero M, Petit‐Kekel K, et al. (2004) Cholesterol supplementation does not improve developmental progress in Smith–Lemli–Opitz syndrome. Journal of Pediatrics 144 (6): 783–791.
The importance of cholesterol ..
Shefer S, Salen G, Batta AK, et al. (1995) Markedly inhibited 7‐dehydrocholesterol‐delta 7‐reductase activity in liver microsomes from Smith–Lemli–Opitz homozygotes. Journal of Clinical Investigation 96 (4): 1779–1785.
Cholesterol biosynthesis pathway
Tierney E, Bukelis I, Thompson R, et al. (2006) Abnormalities of cholesterol metabolism in autism spectrum disorders. American Journal of Medical Genetics 141B: 666–668.
Figure 1: Cholesterol biosynthesis pathway
Rossi M, Vajro P, Iorio R, et al. (2005) Characterization of liver involvement in defects of cholesterol biosynthesis: long‐term follow‐up and review. American Journal of Medical Genetics 132 (2): 144–151.
Cholesterol biosynthesis pathway as a novel …
Jurevics HA, Kidwai FZ and Morell P (1997) Sources of cholesterol during development of the rat fetus and fetal organs. Journal of Lipid Research 38 (4): 723–733.
The Biosynthetic Pathway for Cholesterol: Konrad Bloch
Tint GS, Irons M, Elias ER, et al. (1994) Defective cholesterol biosynthesis associated with the Smith–Lemli–Opitz syndrome. New England Journal of Medicine 330: 107–113.
Disorders of Cholesterol Biosynthesis, Genetics of
Hoffman GF, Gibson KM, Brandt IK, et al. (1986) Mevalonic aciduria: an inborn error of cholesterol and nonsterol isoprene biosynthesis. New England Journal of Medicine 314: 1610–1614.
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