Call us toll-free

The Synthesis of Cholesterol. - Cholesterol-And …

The end products of cholesterol utilization are the bile acids

Approximate price


275 Words


High Cholesterol, APOE Gene and Diet - GB HealthWatch

Cholesterol is an essential component of cell membranes and the precursor for the synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially in a membranous world (especially the last steps), where the enzymes, substrates, and products involved tend to be extremely hydrophobic. The importance of cholesterol has increased in the past half-century because of its association with cardiovascular diseases, which are considered one of the leading causes of death worldwide. In light of the current need for new drugs capable of controlling the levels of cholesterol in the bloodstream, it is important to understand how cholesterol is synthesized in the organism and identify the main enzymes involved in this process. Taking this into account, this review presents a detailed description of several enzymes involved in the biosynthesis of cholesterol. In this regard, the structure and catalytic mechanism of the enzymes involved in cholesterol biosynthesis, from the initial two-carbon acetyl-CoA building block, will be reviewed and their current pharmacological importance discussed. We believe that this review may contribute to a deeper level of understanding of cholesterol metabolism and that it will serve as a useful resource for future studies of the cholesterol biosynthesis pathway.

APOE4 carriers are prone to high cholesterol and Alzheimer's disease

Krakowiak PA, Wassif CA, Kratz L, et al. (2003) Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5‐desaturase deficiency. Human Molecular Genetics 12 (13): 1631–1641.

Cholesterol Chemistry 101 — The Hydroxyl Group

Davis RA, Miyake JH, Hui TY and Spann NJ:Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP.J Lipid Res. 43:533–543. 2002.

Xu G, Salen G, Shefer S, et al. (1995) Treatment of the cholesterol biosynthetic defect in Smith–Lemli–Opitz syndrome reproduced in rats by BM 15.766. Gastroenterology 109 (4): 1301–1307.

Xu G, Servatius RJ, Shefer S, et al. (1998) Relationship between abnormal cholesterol synthesis and retarded learning in rats. Metabolism, Clinical and Experimental 47 (7): 878–882.

Cholesterol Synthesis Pathway - YouTube

Porter J, Porter K and Young P (1996a) Cholesterol modification of hedgehog signaling proteins in animal development. Science 274: 255–259.

Cholesterol is an important biochemical, medical, and commercial molecule. In the pathway for cholesterol biosynthesis, biochemistry textbooks discuss the synthesis of lanosterol from acetate in detail. However, the conversion of lanosterol to cholesterol is most often simply indicated as a multistep process, without elaboration. A pathway for the conversion of lanosterol to cholesterol, based on recent results from the primary research literature, is presented in this paper. Each reaction is discussed, the pathway is discussed within the context of general biochemical transformations, a summary of cholesterol homeostasis is presented, and enzyme deficiencies that give rise to diseases are given.

Wassif CA, Krakowiak PA, Wright BS, et al. (2005) Residual cholesterol synthesis and simvastatin induction of cholesterol synthesis in Smith–Lemli–Opitz syndrome fibroblasts. Molecular Genetics and Metabolism 85 (2): 96–107. Epub February 5.

Cholesterol Biosynthesis | Sigma-Aldrich
Order now
  • Cholesterol biosynthesis and metabolism.

    Cholesterol - Diagnosis:Diet

  • 15/01/2017 · Cholesterol biosynthesis and ..

    Cholesterol levels in the body come from two sources, dietary intake and biosynthesis

  • Lipids Metabolism | Cholesterol | Biosynthesis

    Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals

Order now

Cholesterol Biosynthesis - UMaine Chemistry Department

Sikora DM, Ruggiero M, Petit‐Kekel K, et al. (2004) Cholesterol supplementation does not improve developmental progress in Smith–Lemli–Opitz syndrome. Journal of Pediatrics 144 (6): 783–791.

The importance of cholesterol ..

Shefer S, Salen G, Batta AK, et al. (1995) Markedly inhibited 7‐dehydrocholesterol‐delta 7‐reductase activity in liver microsomes from Smith–Lemli–Opitz homozygotes. Journal of Clinical Investigation 96 (4): 1779–1785.

Cholesterol biosynthesis pathway

Tierney E, Bukelis I, Thompson R, et al. (2006) Abnormalities of cholesterol metabolism in autism spectrum disorders. American Journal of Medical Genetics 141B: 666–668.

Figure 1: Cholesterol biosynthesis pathway

Rossi M, Vajro P, Iorio R, et al. (2005) Characterization of liver involvement in defects of cholesterol biosynthesis: long‐term follow‐up and review. American Journal of Medical Genetics 132 (2): 144–151.

Cholesterol biosynthesis pathway as a novel …

Jurevics HA, Kidwai FZ and Morell P (1997) Sources of cholesterol during development of the rat fetus and fetal organs. Journal of Lipid Research 38 (4): 723–733.

The Biosynthetic Pathway for Cholesterol: Konrad Bloch

Tint GS, Irons M, Elias ER, et al. (1994) Defective cholesterol biosynthesis associated with the Smith–Lemli–Opitz syndrome. New England Journal of Medicine 330: 107–113.

Disorders of Cholesterol Biosynthesis, Genetics of

Hoffman GF, Gibson KM, Brandt IK, et al. (1986) Mevalonic aciduria: an inborn error of cholesterol and nonsterol isoprene biosynthesis. New England Journal of Medicine 314: 1610–1614.

Order now
  • Kim

    "I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."

  • Paul

    "Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."

  • Ellen

    "Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."

  • Joyce

    "Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."

  • Albert

    "Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."

  • Mary

    "Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."

Ready to tackle your homework?

Place an order