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Bacterial synthesis of biodegradable polyhydroxyalkanoates.

Bacterial synthesis of polyhydroxyalkanoates containing aromatic and aliphatic monomers by …

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Bacterial synthesis of biodegradable polyhydroxyalkanoates.

Biodegradation is defined as any physical or chemical change in a material caused by biological activity. Microorganisms such as bacteria, fungi and actinomycetes are involved in the degradation of both natural and synthetic plastics. Plastics are usually biodegraded aerobically in nature, anaerobically in sediments and landfills and partly aerobically in compost and soil. Carbon dioxide and water are produced during aerobic biodegradation, while anaerobic biodegradation produces carbon dioxide, water and methane [].

24/01/2004 · Production of Polyhydroxyalkanoates, a bacterial biodegradable ..
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Steinbüchel, A., (2001). Perspectives for biotechnological production and utilization of biopolymers: metabolic engineering of polyhydroxyalkanoate biosynthesis pathways as a successful example. Macromolecules and. Biosciences, 1, p. 1–24.

Bacterial synthesis of biodegradable ..

Bacterial synthesis of biodegradable polyhydroxyalanoates
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Petroleum product is the chief crude material for the production of synthetic plastic. Today these synthetic plastic materials become an integral part of our daily life because its low production cost and considerable durability. The uncontrolled utilization of these synthetic plastic materials by human beings is hazardous for the environment caused by their disposal as they are not decomposed by bacteria. The biodegradable biopolymers (PHAs) produced from various microorganisms will be a good candidate to replace the petroleum-derived plastics materials by establishment of cost-competitive production of these biopolymers from cheap renewable resources. The development of feasible bioprocesses for the production of biodegradable plastics from cheap renewable resources is possible on the utilization of food industry wastes, dairy waste and from agricultural residue as a substrate. The production of biodegradable plastics materials (PHAs) would be a great revolution in field of biotechnology as they are good substitute of petroleum derived plastics materials. The polyhydroxyalkanoates (PHAs) is a distinctive and most gorgeous biopolymer with a number of industrial and pharmaceutical applications have been studied broadly. Thermoplasticity and biodegradability of PHA have attracted considerable academic and industrial interest since past 20 years. In recent time many scientist works in this field are trying hard to employ and implement the strategy to produce PHAs economically. Approximately 150 hydroxyalkanoic acids other than 3-hydroxybutyrate (3HB) have been identified as constituents of PHA. The most commonly occurring PHA in bacteria is poly (3-hydroxybutyrate) (PHB), which has been commercialized under the trade name BIOPOL. Newly, a novel class of biopolymers, with thioester linkages in place of oxoester bonds, has been found in Ralstonia eutropha and has been classified as polythioesters. This review mainly focuses on the research and development of new PHAs-producing strains, utilization of renewable materials or industrial wastes, and high cell density culture technology for PHAs production.

Verlinden R.A.J., Hill D.J., Kenward M.A., Williams C.D., Radecka I. Bacterial synthesis of biodegradable polyhydroxyalkanoates. Journal of Applied Microbiology, 2007, 102: 1437–1449.

Bacterial synthesis of biodegradable polyhydroxyalkanoates

Bacterial synthesis of biodegradable Polyhydroxyalkanoates.
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Perspectives for biotechnological production and utilization of biopolymers: Metabolic engineering of polyhydroxyalkanoate biosynthesis pathways as a successful example.

An overview of their role in brain physiology and a discussion on the potential of using DHA signaling in the development of treatments in patients suffering from stroke have been released by ().

One neuroprotectin and several resolvins have been shown to be biosynthesized by isolated trout brain cells providing the first evidence for the conservation of these structures from fish to humans as chemical signals in diverse biological systems (.

Production of polyhydroxyalkanoates, a bacterial biodegradable ..
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  • 19/01/2018 · Fatimah Alshehrei

    Biodegradation of Synthetic and Natural Plastic by Microorganisms

  • Journal of Applied & Environmental Microbiology


  • Biological degradation of plastics: A comprehensive …

    5, No

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Biodegradation of blend films PVA/PVC, PVA/PCL in soil …

The study of cancer cell has been hindered by the lack of appropriate ex vivo models, which can mimic this microenvironment. It is hypothesized that the fabrication of porous 3-D scaffolds for the biomimetics growth of cancer cells ex vivo could facilitate the study of the disease in its native 3-D niche. For that reason, biomaterials are used for fabrication of 3-D scaffold, in general, may be natural polymers such as proteins, collagens and gelatin, or synthetic biopolymers. Among the various available biodegradable polymers, polyhydroxyalkanoates (PHAs) have gained significant interest as one of the value-added materials which can be synthesized from abundantly available source of palm oil mill effluent (POME). Down the group of the PHA, poly-3-hydroxybutyrate (PHB) and copolymerizing this PHB that produced PHBVs; these two polymers have the most prevalent polymer used for scaffolds fabrication. A physico-chemical and biological modification has developed to improve wetting, adhesion, and printing of polymer surfaces, generally by introducing a variety of polar groups. These techniques must be tailored to introduce a specific functional group when the surface modification is a precursor to attach a bioactive compound. There are a few methods in order to fabricate porous 3-D scaffolds such as solvent casting, particulate leaching, thermally induced phase separation, gas forming, fiber bonding, electrospinning and also solid free form method. A review of the polyhydroxyalkanoates (PHAs) for tissue engineering applications is presented, beginning with the basic naturally derived polymerization of PHAs, biotransformation of palm oil mill effluent (POME) to the value-added polymers, novel methods of scaffold fabrication capabilities and its physico-chemical and biological surface modifications to increase cell-biomaterial affinity.

Bioengineering | An Open Access Journal from MDPI

Zinn, M., Witholt, B., Egli, T. 2001. Occurrence, Synthesis and Medical Application of Bacterial Polyhydroxyalkanoate. Advanced Drug Delivery Reviews. 53(1): 5-21.

Bioengineering, an international, peer-reviewed Open Access journal.

Increased and accelerated global economic activities over the past century have led to interlinked problems that require urgent attention. The current patterns of production and consumption have raised serious concerns. In this context, greater emphasis has been put on the concept of sustainable economic systems that rely on technologies based on and supporting renewable sources of energy and materials. Average UK households produce around 3.2 million tonnes of packaging waste annually whereas 150 million tonnes of packaging waste is generated annually by industries in the UK. Hence, the development of biologically derived biodegradable polymers is one important element of the new economic development. Key among the biodegradable biopolymers is a class known as polyhydroxyalkanoates. Polyhydroxyalkanoates (PHAs) are a family of polyhydroxyesters of 3-, 4-, 5- and 6-hydroxyalkanoic acids, produced by a variety of bacterial species under nutrient-limiting conditions with excess carbon. These water-insoluble storage polymers are biodegradable, exhibit thermoplastic properties and can be produced from renewable carbon sources. Thus, there has been considerable interest in the commercial exploitation of these biodegradable polyesters. In this review various applications of polyhydroxyalkanoates are discussed, covering areas such as medicine, agriculture, tissue engineering, nanocomposites, polymer blends and chiral synthesis. Overall this review shows that polyhydroxyalkanoates are a promising class of new emerging biopolymers.

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